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Wegovy is injected once a week, on the same day each week

Interestingly, DPP-4 inhibition does not have to take place systemically but only in the intestine as shown with oral administration of low doses of inhibitor (122)

There is a higher chance of damage in digestion, which can cause bloating, or nausea, particularly at high doses

Both help reduce appetite, but they act on different pathways in the brain. GIP and Glucagon Retatrutide, an experimental triple agonist drug that targets GIP, GLP-1, and glucagon, is currently being studied and has not yet been approved by the U.S

While the exact reason is unclear, it is hypothesized that Wegovys tendency to cause gastrointestinal side effects such as nausea, vomiting, and diarrhea